Neoadjuvant immunotherapy shows promise

Preliminary breast cancer vaccine study shows promise.

A vaccine designed to treat breast cancer has performed surprisingly well in an initial clinical study. In a phase II trial of 186 patients, the vaccine targeting the HER2/neu E75 peptide reduced the risk of recurrence by 50% in 101 breast cancer patients who were clinically disease free after treatment compared with those who were not treated with the vaccine. Immunized patients also had about...

Gene therapy for Parkinson's disease shows promise.

CLINICAL TRIALS NEUROLOGICAL DISEASES ARE AMONG THE MOST INTERESTING APPLICATIONS FOR gene therapy. A er decades of preclinical development, viral vector–based gene transfer has now reached the clinic, and early-stage clinical trials are currently in progress in three areas: congenital blindness and retinal degeneration; the childhood metabolic disorder Bat-ten disease; and the progressive neur...

Trials and tribulations of cancer immunotherapy: the dendritic cell vaccine shows promise in a phase I glioblastoma multiforme trial.

Polypill Shows Promise for Reducing Cardiovascular Disease Risk Factors

Setting and participants. Between March 2007 and August 2008, 2053 individuals aged 45 to 80 years were recruited from 50 centers across India if they had no cardiovascular disease (CVD) but at least 1 of the following CVD risk factors: smoker within past 5 years, type 2 diabetes, blood pressure >140 mm Hg systolic or 90 mm Hg diastolic, abnormal lipid levels (low-density lipoprotein [LDL] chol...

Osteopathic Manipulative Therapy Shows Promise for Improving Postdiskectomy Recovery.

The Journal of the American Osteopathic Association October 2015 | Vol 115 | No. 10 because the change was less than 25%, the cutoff for clinical relevancy. The authors conclude that this finding adds to the building evidence for the safety of cervical spine manipulation with regard to vertebral artery derangement. As a contributor in the past decade to the American Osteopathic Association’s ef...